The Breast Cancer Gene Database (BCGD) is a compendium of molecular genetic data relating to genes involved in breast cancer, and which is freely available via the World Wide Web. You are using a browser version with limited support for CSS. Currently, the database contains a reasonably comprehensive list of the genes which have been shown with some certainty to be important in Breast Cancer, the various names given to each of these genes, and a useful collection of basic facts about these genes; subcellular location, size, biochemical activity, and so forth. and JavaScript. There are plans to create a prostate and colon-specific extensions of TGDB as well. "breast cancer") to get started.Then, click on the tab that says "OMIM dbSNP" to limit results to those loci with a known SNP. 27: 39–43. Benson DA, Boguski MS, Lipman DJ, Ostell J, Ouellette BF, Rapp BA and Wheeler DL. Cancer Facts and Figures 2010. This initial search misses many references which concern a Breast Cancer Gene, but which report results which themselves are not particular to Breast Cancer. Genes that increase the risk of breast cancer are BRCA1 and BRCA2. The primary report for the fact might be the cited paper, or the cited paper might report the fact as coming from one of its references. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Further, The mechanisms for collaborative curation of a gene or set of genes by researchers throughout the world, the mechanisms for editorial oversight by experts in the field (capabilities unique among biological databases of this type) will facilitate its maintenance. (An analogous comparison is between a dictionary and a book containing the same words and definitions in random order). Cancer Letters 77 (1994) 163-171. sequence databases such as GenBank (Benson et al., 1999), EMBL (Stoesser et al., 1999), DDBJ (Tateno and Gojobori, 1997), SwissProt (Bairoch and Apweiler, 1999), and PIR (Barker et al., 1999)) to resources for consumer health (e.g. Primary facts are, of course, rare or absent from most reviews. The database fact listing for BRCA1 under the Topic `Cell location' variously lists the cytoplasm and secretory vesicles as well as the nucleus (not shown). Men can also have breast cancer, although male breast cancer is rare. One of the serious impediments to achieving clinical benefits from this information however, is finding and assessing the significance of mutations … Currently, searches with multiple keywords are treated as a logical `OR'. Basal-like subtype shares many genetic features with high-grade serous ovarian cancer, suggesting that the cancers have a common molecular origin and may share therapeutic opportunities, such as: A drug that inhibits blood vessel growth, cutting off the blood supply to the tumor. This approach has the added benefit of providing a natural way to divide references among curators and to make the task of extracting data from these publications more manageable. Breast cancer is the most frequent tumor in women. Despite the fact that it is heavily based on PubMed, a researcher would not be able to extract the information in BCGD from PubMed without duplicating the many hours of work performed by BCGD curators. transgenic mice) which overlaps little with BCGD. A significant effort was made to include within BCGD as complete a synonym table as possible, allowing a user to query the database and retrieve all relevant facts using any one of the gene names. 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